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Home Antibody All anti-ULK1 antibodies

Anti-ULK1 PHOSPHO Antibody EPR6155

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310924
  • Rabbit Monoclonal antibody against ULK1, pS638 (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for ULK1 (NM_003565)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 638 of human ULK1 was used as an immunogen. This antibody only detects ULK1 phosphorylated at Serine 638.
Clone NameEPR6155 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens unc-51 like autophagy activating kinase 1 (ULK1)
Alternative NameATG1; ATG1A; hATG1; UNC51; Unc51.1
Database LinkNP_003556
Entrez Gene 8408 Human
FunctionULK1 is a serine/threonine kinase that promotes autophagy signaling (1). It forms a complex with mammalian Atg13 (mAtg13) and FIP200. In this complex, mAtg13 mediates the interaction between FIP200 and ULK1 and is required for the phosphorylation of FIP200 by ULK1 in response to nutrient starvation. mTORC1 associates with the ULK1-mAtg13-FIP200 complex through an interaction between raptor and ULK1, phosphorylating ULK1 and mAtg13 to repress the kinase activity of ULK1, thereby suppressing the initiation of autophagy (2). Moreover, ULK1 is involved in the regulation of neurotransmitter trafficking and axonal growth (3).
Related PathwayProtein KinaseDruggable Genome Regulation of autophagymTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ULK1 (phospho S638) antibody [EPR6155]; All lanes : Anti-ULK1 (phospho S638) antibody [EPR6155] at 1/1000 dilution.Lane 1 : ULK1 transfected 293T cell lysate.Lane 2 : ULK1 transfected 293T cell lysate, treated with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 112 kDa.
Assay Image
Other-Anti-ULK1 (phospho S638) antibody [EPR6155](TA310924); Equilibrium disassociation constant (KD)..

 

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