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Home Antibody All anti-ULK1 antibodies

Anti-ULK1 Antibody EPR4885(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310922
  • Rabbit Monoclonal antibody against ULK1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418585) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
Assay(1)
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Also for ULK1 (NM_003565)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ULK1 was used as an immunogen.
Clone NameEPR4885(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
Predicted MW Explanation 112 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens unc-51 like autophagy activating kinase 1 (ULK1)
Alternative NameATG1; ATG1A; hATG1; UNC51; Unc51.1
Database LinkNP_003556
Entrez Gene 8408 Human
Entrez Gene 22241 Mouse
Entrez Gene 360827 Rat
FunctionULK1 is a serine/threonine kinase that promotes autophagy signaling (1). It forms a complex with mammalian Atg13 (mAtg13) and FIP200. In this complex, mAtg13 mediates the interaction between FIP200 and ULK1 and is required for the phosphorylation of FIP200 by ULK1 in response to nutrient starvation. mTORC1 associates with the ULK1-mAtg13-FIP200 complex through an interaction between raptor and ULK1, phosphorylating ULK1 and mAtg13 to repress the kinase activity of ULK1, thereby suppressing the initiation of autophagy (2). Moreover, ULK1 is involved in the regulation of neurotransmitter trafficking and axonal growth (3).
Related PathwayProtein KinaseDruggable Genome Regulation of autophagymTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ULK1 antibody [EPR4885(2)]; All lanes : Anti-ULK1 antibody [EPR4885(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : U87 MG cell lysate.Lane 3 : PC12 cell lysate.Lane 4 : Fetal muscle lysate.Lane 5 : SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 112 kDa.Observed band size : 120 kDa .
Assay Image
Other-Anti-ULK1 antibody [EPR4885(2)](TA310922); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ULK1 antibody [EPR4885(2)]; TA310922, at 1/100 dilution, staining ULK1 in paraffin embedded Human kidney tissue by Immunohistochemistry.

 

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