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Home Antibody All anti-UCMA antibodies

Anti-UCMA Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306793
  • Rabbit Polyclonal UCMA Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC407961) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenUCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2.5 - 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens upper zone of growth plate and cartilage matrix associated (UCMA)
Alternative NameC10orf49; GRP; GRP/UCMA
Database LinkNP_660357
FunctionUCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.
Related Pathway

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WB Image
Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5 µg/ml.

 

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