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Home Antibody All anti-UBQLN4 antibodies

Anti-UBQLN4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306810
  • Rabbit Polyclonal CIP75 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402751) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for UBQLN4 (NM_020131)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ubiquilin 4 (UBQLN4)
Alternative NameA1U; A1Up; C1orf6; CIP75; UBIN
Database LinkNP_064516
Entrez Gene 56893 Human
Entrez Gene 94232 Mouse
Entrez Gene 310633 Rat
FunctionThe ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CIP75 in 3T3 cell lysate with CIP75 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of CIP75 in mouse kidney tissue with CIP75 antibody at 5 ug/ml.

 

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