Home Antibody All anti-UBE2N antibodies
Also for UBE2N (NM_003348)
|UBC13 antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBC13.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens ubiquitin-conjugating enzyme E2N (UBE2N)|
|UBC13; UbcH-ben; UbcH13|
|Ubiquitin-conjugating enzyme 13 (Ubc13) was initially discovered in S. cerevisiae as a DNA-damage inducible protein involved in the error-free DNA postreplication repair pathway (1). It has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). Ubc13 is part of a dimeric ubiquitin-conjugating enzyme complex also containing UEV1A (ubiquitin-conjugating enzyme E2 variant 1) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).|
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Western blot analysis of UBC13 in human small intestine cell lysates with UBC13 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of UBC13 in mouse thymus tissue with UBC13 antibody at 2 ug/ml.