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Anti-UBB Antibody

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SKU Description Amount Price Availability*  
TA322285
  • Anti-UBB Rabbit Polyclonal Antibody
100ul $325 2-3 Weeks
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IHC(1)

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 102-229 amino acids of Human Polyubiquitin-B
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.7mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:500-2000, IHC: 1:25-50
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens ubiquitin B (UBB), transcript variant 1
Alternative NameRPS27A; UBA52; UBC
Database LinkNP_061828
FunctionThis gene encodes ubiquitin; one of the most conserved proteins known. Ubiquitin is required for ATP-dependent; nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded; and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation; suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently; the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.?
Related Pathway
Cell cycle

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IHC Image
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/25-50 The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using UBB antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification: x200)

 

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