Home Antibody All anti-Tnfaip3 antibodies
Also for Tnfaip3 (NM_006290)
|TNFAIP3 antibody was raised against a 17 amino acid peptide near the center of human TNFAIP3.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), transcript variant 3|
|A20; OTUD7C; TNFA1P2|
Entrez Gene 7128 Human
Entrez Gene 21929 Mouse
Entrez Gene 683206 Rat
|TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.|
|Druggable Genome NOD-like receptor signaling pathway|
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Western blot analysis of TNFAIP3 in rat lung tissue lysate with TNFAIP3 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of TNFAIP3 in human lung tissue with TNFAIP3 antibody at 5 ug/ml.