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Home Antibody All anti-Tnfaip3 antibodies

Anti-Tnfaip3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306770
  • Rabbit Polyclonal TNFAIP3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC416749) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for Tnfaip3 (NM_006290)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTNFAIP3 antibody was raised against a 17 amino acid peptide near the center of human TNFAIP3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), transcript variant 3
Alternative NameA20; OTUD7C; TNFA1P2
Database LinkNP_006281
FunctionTNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of TNFAIP3 in rat lung tissue lysate with TNFAIP3 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of TNFAIP3 in human lung tissue with TNFAIP3 antibody at 5 ug/ml.

 

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