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Anti-TYW1 Antibody Polyclonal
Also for TYW1 (NM_018264)
|TYW1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TYW1.|
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml
|TYW1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TYW1 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) (TYW1)|
|RSAFD1; TYW1A; YPL207W|
|TYW1 Antibody: TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions|
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Western blot analysis of TYW1 in human lung tissue lysate with TYW1 antibody at 1 ug/mL.
Immunohistochemistry of TYW1 in human lung tissue with TYW1 antibody at 5 ug/mL.