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Also for TYK2 (NM_003331)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 680 and 1176 of TYK2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens tyrosine kinase 2 (TYK2)|
|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq]|
Jak-STAT signaling pathway
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Sample(30 ug whole cell lysate) A:H1299 B:HeLa S3 (anti-TYK2 antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TYK2(anti-TYK2 antibody) antibody at 1:200 dilution.