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Anti-TTR Antibody EPR3219
|A synthetic peptide corresponding to residues in human Prealbumin was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000~5000; IHC: 1: 100~250; FC: 1:80
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens transthyretin (TTR)|
|CTS; CTS1; HsT2651; PALB; TBPA|
|Prealbumin (TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Prealbumin concentrations are disproportionately high in human ventricular cerebrospinal fluid (CSF). It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in prealbumin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of prealbumin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble prealbumin fibrils (2). |
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Western blot - Prealbumin antibody; All lanes : Anti-Prealbumin antibody [EPR3219] at 1/1000 dilution.Lane 1 : Human plasma lysate.Lane 2 : Human placenta lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 16 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prealbumin antibody [EPR3219]; ab92469, at a 1/100 dilution, staining Prealbumin in paraffin embedded Human liver tissue by Immunohistochemistry.