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Home Antibody All anti-TSC22D3 antibodies

Anti-TSC22D3 Antibody CFMKG15

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320507
  • Rat Anti-Human/Mouse GILZ Purified (25 ug)
25ug $120 3-7 Days
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WB(1)

OriGene Data

Immunogen
Clone NameCFMKG15 Isotype
Species ReactivityMouse Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *WB Suggested DilutionsFlow, ICC, WB
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameMus musculus TSC22 domain family, member 3 (Tsc22d3), transcript variant 2
Alternative NameDIP; Dsip1; Gilz; Tilz3; TSC-22R
Database LinkNP_034416
FunctionGILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-κB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-κB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.
Related Pathway

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WB Image
Left: Immunoblot of mouse thymocytes cultured without (lane 1) or with (lane 2) dexamethasone (10e-7 M) for 3 hr. The membrane was probed with 10 ug/mL of Anti-Human/Mouse GILZ Purified, followed by Anti-Rat IgG HRP. Right: Immunoblot of normal human peripheral blood cells cultured without (lane 1) or with (lane 2) dexamethasone (10e-7 M) for 3 hr. The membrane was probed with 2 ug/mL of Anti-Human/Mouse GILZ Purified, followed by Anti-Rat IgG HRP.

 

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