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Home Antibody All anti-TRPM4 antibodies

Anti-TRPM4 TRUEMAB Antibody Clone OTI14C3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500368 anti-TRPM4 mouse monoclonal antibody, clone OTI14C3 (formerly 14C3) 100ul $325 In Stock
LC413636 TRPM4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500368 Carrier-free (BSA/glycerol-free) TRPM4 mouse monoclonal antibody, clone OTI14C3 (formerly 14C3) 100ug $450 3-4 weeks
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WB(2)
IHC(2)
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Also for TRPM4 (NM_017636)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull-length protein expressed in 293T cell transfected with human TRPM4 expression vector
Clone NameClone OTI14C3 IsotypeIgG1
Species ReactivityHuman Concentration0.7 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:1000, IHC 1:50
Predicted MW Explanation 134.3 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens transient receptor potential cation channel, subfamily M, member 4 (TRPM4), transcript variant 1
Alternative NamePFHB1B; TRPM4B
Database LinkNP_060106
Entrez Gene 54795 Human
FunctionCalcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload
Related PathwayIon Channels: Transient receptor potentialTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (RC216888, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRPM4.
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Western blot analysis of extracts (10ug) from 1 cell line by using anti-TRPM4 monoclonal antibody.(1:200)
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Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-TRPM4mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500368, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-TRPM4mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500368, Dilution 1:50)
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