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Home Antibody All anti-TRPC6 antibodies

Anti-TRPC6 Antibody

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SKU Description Amount Price Availability*  
TA306348
  • Rabbit Polyclonal TRPC6 Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenTRPC6 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TRPC6.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transient receptor potential cation channel, subfamily C, member 6 (TRPC6)
Alternative NameFSGS2; TRP6
Database LinkNP_004612
FunctionThe mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types (1). Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Related Pathway

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WB Image
Western blot analysis of TRPC6 in mouse lung tissue lysate with TRPC6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of TRPC6 in mouse lung tissue with TRPC6 antibody at 10 ug/ml.

 

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