Home Antibody All anti-TRPC3 antibodies
Also for TRPC3 (NM_001130698)
|TRPC3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human TRPC3.|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transient receptor potential cation channel, subfamily C, member 3 (TRPC3), transcript variant 1|
Entrez Gene 7222 Human
Entrez Gene 22065 Mouse
|The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors (2). TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.|
|Ion Channels: Transient receptor potentialTransmembraneDruggable Genome |
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Western blot analysis of TRPC3 in mouse heart tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 10 ug/ml.