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Anti-TRIP10 Antibody EPR1966(2)
Also for TRIP10 (NM_004240)
|A synthetic peptide corresponding to residues in human CIP4 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens thyroid hormone receptor interactor 10 (TRIP10), transcript variant 2|
|CIP4; HSTP; STOT; STP; TRIP-10|
Entrez Gene 9322 Human
Entrez Gene 106628 Mouse
Entrez Gene 116717 Rat
|CIP4 (Cdc42-interacting protein 4) is a Cdc42 effector that is required for the translocation of GLUT4 to the plasma membrane in response to insulin signaling. It is involved in coordinating membrane tabulation, with reorganization of the actin cytoskeleton during endocytosis. CIP4 binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination and the formation of tubules. It promotes Cdc42-induced actin polymerization by recruiting WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. CIP4 is also required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Furthermore, CIP4 interacts with GTP-bound RHOQ. It is expressed in the brain, colon, heart, kidney, and other tissues (1).|
|Druggable Genome Insulin signaling pathway|
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Western blot - Cip4 antibody [EPR1966(2)]; All lanes : Anti-Cip4 antibody [EPR1966(2)] at 1/1000 dilution.Lane 1 : JAR lysate.Lane 2 : HepG2 lysate.Lane 3 : TF1 lysate.Lane 4 : HeLa lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 68 kDa.