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Anti-TRIM33 Antibody Polyclonal
Also for TRIM33 (NM_015906)
|TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|TRIM33 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TRIM33 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens tripartite motif containing 33 (TRIM33), transcript variant a|
|ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA|
|TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).|
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Western blot analysis of TRIM33 in human liver tissue lysate with TRIM33 antibody at (A) 1 and (B) 2 ug/mL.