Home Antibody All anti-TRAF3IP2 antibodies
Also for TRAF3IP2 (NM_001164281)
|CIKS antibody was raised against a synthetic peptide corresponding to amino acids 2 to 15 of human CIKS .|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 3|
|ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13|
|Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB associates with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kappaB activator 1) (1,2). CIKS directly interacts with IKKgamma. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.|
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Western blot analysis of CIKS expression in human lung (lane A) and placenta (lane B) tissue lysates with CIKS antibody at 1 ug /ml.
Immunohistochemistry of CIKS in human lung tissue with CIKS antibody at 5 ug/ml.