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Home Antibody All anti-TRAF3 antibodies

Anti-TRAF3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306250
  • Rabbit Polyclonal TRAF3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418781) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TRAF3 (NM_003300)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTRAF3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 - 4 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 3
Alternative NameCAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Database LinkNP_003291
Entrez Gene 7187 Human
Entrez Gene 22031 Mouse
Entrez Gene 362788 Rat
FunctionTumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.
Related PathwayDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TRAF3 in HeLa cell lysate with TRAF3 antibody at (A) 2 and (B) 4 ug/mL.
IF Image
Immunocytochemistry of TRAF3 in HeLa cells with TRAF3 antibody at 10 ug/mL.

 

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