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Home Antibody All anti-TRAF3 antibodies

Anti-TRAF3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306249
  • Rabbit Polyclonal TRAF3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418781) , 20ug
100ug $325 In Stock
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WB(1)
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Also for TRAF3 (NM_003300)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTRAF3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TRAF3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 3
Alternative NameCAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Database LinkNP_003291
FunctionTumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR (5).
Related Pathway
Apoptosis
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of TRAF3 in 3T3 cell lysate with TRAF3 antibody at (A) 1, and (B) 2 µg/ml.

 

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