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Home Antibody All anti-TRAF2 antibodies

Anti-TRAF2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319201 Rabbit polyclonal anti-TRAF2 antibody 100ug $325 3-7 Days
LC402843 TRAF2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region human TRAF2.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse Concentration0.93 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:60,000 - 1:250,000, WB: 1 ug/mL, IF: user optimized
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note TRAF2, or Tumor Necrosis factor (TNF) Receptor-Associated Factor 2, is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. TRAF2 mediates activation of NF-kappa-B and MAPK8/JNK and is involved in apoptosis. TRAF2 forms a heterodimeric complex with TRAF1, which then recruits the inhibitor-of-apoptosis proteins (IAPs), apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 for the inhibition of caspase activation. In this way it functions as a mediator of the anti-apoptotic signals from TNF receptors. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. TRAF2 may be involved in IL-15 signaling. Multiple alternatively spliced transcript variants exist, but the biological validity of only one transcript has been determined.

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 2 (TRAF2)
Alternative NameMGC:45012; TRAP; TRAP3
Database LinkNP_066961
Entrez Gene 7186 Human
Entrez Gene 22030 Mouse
Related PathwayDruggable Genome MAPK signaling pathwayApoptosisRIG-I-like receptor signaling pathwayAdipocytokine signaling pathwayPathways in cancerSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
WB using Anti-TRAF2 antibody shows detection of endogenous TRAF2 in whole HeLa cell lysates. Lane 2 shows endogenous TRAF2 detected with antibody at 47 kDa (arrowhead). Lane 4 shows no reactivity when blot is incubated with immunizing peptide. Briefly, each lane contains approximately 14 µg of lysate. Primary antibody was used at 1:500. Gt-a-Rabbit DyLight 649 was used at 1:20000.


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