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Home Antibody All anti-TRAF2 antibodies

Anti-TRAF2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306276
  • Rabbit Polyclonal TRAF2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402843) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TRAF2 (NM_021138)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTRAF2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TRAF2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 2 (TRAF2)
Alternative NameMGC:45012; TRAP; TRAP3
Database LinkNP_066961
FunctionTumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress (1). TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity (2), and are critical for NF-kappaB activation in mouse B lymphocytes (3). TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells (4). TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac (5).
Related Pathway
Apoptosis
MAPK signaling pathway

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WB Image
Western blot analysis of TRAF2 in mouse liver tissue lysate with TRAF2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of TRAF2 in mouse liver tissue with TRAF2 antibody at 10 ug/ml.

 

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