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Anti-TPPP Antibody EPR3315
Also for TPPP (NM_007030)
|A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; IP: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or ICC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens tubulin polymerization promoting protein (TPPP)|
|p24; p25; p25alpha; TPPP/p25; TPPP1|
|Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein, and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA), a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal human brains (2).|
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Western blot - Anti-Tubulin Polymerization Promoting Protein antibody [EPR3315]; All lanes : Anti-Tubulin Polymerization Promoting Protein antibody [EPR3315] at 1/1000 dilution.Lane 1 : Human fetal brain lysate.Lane 2 : SH-SY5Y cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 23 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tubulin Polymerization Promoting Protein antibody [EPR3315]; ab119987 at 1/100 dilution staining Tubulin Polymerization Promoting Protein in Paraffin-embedded Human astrocytoma tissue by Immunohistochemistry.