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Anti-TPO Antibody EPR5379
|A synthetic peptide corresponding to residues in the extracellular domain in human TPO was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for IHC-P.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for IHC-P.
|Homo sapiens thyroid peroxidase (TPO), transcript variant 1|
|MSA; TDH2A; TPX|
|TPO is a membrane-bound glycoprotein. It acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in TPO are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA (1).|
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Jak-STAT signaling pathway
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Western blot - Anti-Thyroid Peroxidase antibody [EPR5379]; Anti-Thyroid Peroxidase antibody [EPR5379] at 1/1000 dilution + Human thyroid lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 103 kDa.