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Home Antibody All anti-TPMT antibodies

Anti-TPMT TRUEMAB Antibody Clone OTI4C1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501054 anti-TPMT mouse monoclonal antibody, clone OTI4C1 (formerly 4C1) 100ul $379 In Stock
LC400131 TPMT HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501054 Carrier-free (BSA/glycerol-free) TPMT mouse monoclonal antibody, clone OTI4C1 (formerly 4C1) 100ug $450 3-4 Days
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WB(2)
IHC(3)
FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human TPMT (NP_000358) produced in HEK293T cell.
Clone NameClone OTI4C1 IsotypeIgG1
Species ReactivityHuman, Dog Concentration0.88 mg/ml
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB 1:2000, IHC 1:50, Flow 1:100
Predicted MW Explanation 28.2kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens thiopurine S-methyltransferase (TPMT)
Alternative NameOTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase
Database LinkNP_000358
Entrez Gene 7172 Human
Entrez Gene 403536 Dog
FunctionThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Related PathwayDruggable Genome Drug metabolism - other enzymes

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TPMT (RC203309, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TPMT.
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WB analysis of extracts (35ug) from 9 different cell lines by using anti-TPMT monoclonal antibody.
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Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501054, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501054, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded pancreas tissue within the normal limits using anti-PIM2 mouse monoclonal antibody. (TA501062, Dilution 1:50; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min)
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HEK293T cells transfected with either pCMV6-ENTRY TPMT(RC203309)(Red) or empty vector control plasmid(Blue) were immunostained with anti-TPMT mouse monoclonal(TA501054), and then analyzed by flow cytometry.
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