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Home Antibody All anti-TPMT antibodies

Anti-TPMT TRUEMAB Antibody clone 5B4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500965
  • anti-TPMT mouse monoclonal antibody, clone 5B4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400131) , 20ug
100ul 325 In Stock
CF500965
  • Carrier-free (BSA/glycerol-free) TPMT mouse monoclonal antibody, clone 5B4
100ug $450 3-4 weeks
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WB(1)
IHC(4)
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Also for TPMT (NM_000367)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human TPMT (NP_000358) produced in HEK293T cell.
Clone Nameclone 5B4 IsotypeIgG1
Species ReactivityHuman Concentration0.60 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:1000, IHC 1:50,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens thiopurine S-methyltransferase (TPMT)
Alternative NameOTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase
Database LinkNP_000358
FunctionThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TPMT (RC203309, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TPMT.
IHC Image
Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500965, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded liver tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500965, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded prostate tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500965, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500965, Dilution 1:50)

 

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