Anti-TP63 Antibody, Clone 6D1

Also for TP63 (NM_003722)

OriGene Data

Immunogen	Full length human recombinant protein of human TP63 (NP_003713) produced in SF9 cell.
Clone Name	Clone 6D1	Isotype	IgG2a
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:2000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens tumor protein p63 (TP63), transcript variant 1
Alternative Name	AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
Database Link	NP_003713
Function	This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].
Related Pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP63 (RC208013, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TP63.

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-${SYMBOL} mouse monoclonal antibody. (TA801797)

IHC Image

Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-${SYMBOL} mouse monoclonal antibody. (TA801797)

IHC Image

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-${SYMBOL} mouse monoclonal antibody. (TA801797)

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-TP63 TrueMAB Antibody Clone 6D1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data