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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody EPR358(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301314
  • Rabbit Monoclonal Antibody against TP53 (Clone EPR358(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400186) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic acetylated peptide corresponding to residues surrounding K382 of human p53 was used as an immunogen. The antibody only detects p53 acetylated on Lysine 382.
Clone NameEPR358(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:250 - 1:5000; ICC: 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Entrez Gene 7157 Human
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. p53 is acetylated at lysine 382 upon Ras expression, an event that is essential for its biological function (4). Acetylation at lysine 382 specifically determines the PAb421 epitope (5).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p53 (acetyl K382) antibody [EPR358(2)]; All lanes : Anti-p53 (acetyl K382) antibody [EPR358(2)] at 1/5000 dilution.Lane 1 : HepG2 cell lysates un-treated.Lane 2 : HepG2 cell lysates treated with etopside and TSA.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.

 

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