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Anti-TP53 Antibody EP42Y
Also for TP53 (NM_000546)
|A synthetic phospho-peptide corresponding to residues surrounding serine 46 of human p53 protein.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000; IP: 1:40; IHC-P: 1:100 - 1:250; ICC: 1:50
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt.
|Homo sapiens tumor protein p53 (TP53), transcript variant 1|
|BCC7; LFS1; P53; TRP53|
|p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. Due to UV-induced DNA damage, p53 is phosphorylated on eight different serine/threonine locations on the N-terminal. Phospholyation on serine 46 has been implicated as a mediator in apoptosis induced by DNA-damage (4, 5). |
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - p53 (phospho S46) antibody [EP42Y]; All lanes : Anti-p53 (phospho S46) antibody [EP42Y] at 1/2000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : HepG2 cell lysate treated with etoposide.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p53 (phospho S46) antibody [EP42Y]; Immunohistochemical analysis of human ovarian adenocarcinoma using TA301062 at 1/100 dilution.