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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody Y5

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300331
  • Rabbit Monoclonal Antibody against TP53 (Clone Y5)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400186) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(5)
Assay(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to N-terminal residues human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.
Clone NameY5 IsotypeIgG
Species ReactivityHuman, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:500; IHC: 1:50; ICC: 1: 100; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).
Related Pathway
Apoptosis
Cell cycle
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p53 antibody [Y5]; Anti-p53 antibody [Y5] at 1/500 dilution + A431 cell lysate.Predicted band size : 44 kDa.Observed band size : 50 kDa .
Assay Image
Other-Anti-p53 antibody [Y5](TA300331); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - p53 antibody [Y5]; Immunohistochemistry (Paraffin-embedded sections) using TA300331 at a dilution of 1/50 and human skin cancer
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody [Y5]; TA300331 showing positive staining in Glioma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 antibody [Y5](TA300331); TA300331 showing positive staining in Gastric adenocarcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 antibody [Y5](TA300331); TA300331 showing positive staining in Urinary bladder carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 antibody [Y5](TA300331); TA300331 showing positive staining in Breast carcinoma tissue.

 

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