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Home Antibody All anti-TOP2A antibodies

Anti-TOP2A Antibody EP1102Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303721
  • Rabbit monoclonal antibody against Topoisomerase II Alpha (Topo Iia)(EP1102Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420704) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to C-terminal residues of human Topo IIa was used as an immunogen.
Clone NameEP1102Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000; IP: 1:50; IHC-P: Use at an assay dependent dilution
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)
Alternative NameTOP2; TP2A
Database LinkNP_001058
Entrez Gene 7153 Human
Entrez Gene 21973 Mouse
Entrez Gene 360243 Rat
FunctionThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq].
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Topoisomerase II alpha antibody [EP1102Y]; Anti-Topoisomerase II alpha antibody [EP1102Y] at 1/10000 dilution + HeLa cell lysate at 10 ug.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 174 kDa.
Assay Image
Other-Anti-Topoisomerase II alpha antibody [EP1102Y](TA303721); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Topoisomerase II alpha antibody [EP1102Y]; Immunohistochemical analysis of paraffin-embedded human breast carcinoma using TA303721 at a dilution of 1/100-1/250.

 

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