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Anti-TOP2A Antibody EP1102Y
Also for TOP2A (NM_001067)
|A synthetic peptide corresponding to C-terminal residues of human Topo IIa was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000; IP: 1:50; IHC-P: Use at an assay dependent dilution
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)|
Entrez Gene 7153 Human
Entrez Gene 21973 Mouse
Entrez Gene 360243 Rat
|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq]. |
|Druggable Genome |
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Western blot - Topoisomerase II alpha antibody [EP1102Y]; Anti-Topoisomerase II alpha antibody [EP1102Y] at 1/10000 dilution + HeLa cell lysate at 10 ug.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 174 kDa.
Other-Anti-Topoisomerase II alpha antibody [EP1102Y](TA303721); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Paraffin-embedded sections) - Topoisomerase II alpha antibody [EP1102Y]; Immunohistochemical analysis of paraffin-embedded human breast carcinoma using TA303721 at a dilution of 1/100-1/250.