Home Antibody All anti-TOLLIP antibodies
Also for TOLLIP (NM_019009)
|TOLLIP antibody was raised against a 16 amino acid peptide from near the center of human TOLLIP.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens toll interacting protein (TOLLIP)|
Entrez Gene 54472 Human
Entrez Gene 54473 Mouse
Entrez Gene 361677 Rat
|Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.|
|Druggable Genome Toll-like receptor signaling pathway|
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Western blot analysis of TOLLIP in rat brain cell lysate with TOLLIP antibody at (A) 0.5, (B) 1 and (C) 2ug/mL.
Immunocytochemistry of TOLLIP in THP-1 cells with TOLLIP antibody at 2 ug/mL.