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Home Antibody All anti-TNPO3 antibodies

Anti-TNPO3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306573
  • Rabbit Polyclonal TNPO3 Antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenTNPO3 antibody was raised against a 18 amino acid peptide from near the amino terminus of human TNPO3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transportin 3 (TNPO3), transcript variant 1
Alternative NameIPO12; LGMD1F; MTR10A; TRN-SR; TRN-SR2; TRNSR
Database LinkNP_036602
FunctionTNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of TNPO3 in rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2 µg/ml.

 

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