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Anti-TNNT2 Antibody EPR3695
Also for TNNT2 (NM_000364)
|A synthetic peptide corresponding to residues in human Troponin T type 2 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||IHC: 1:100 - 250, IP: 1:10, WB: 1:100,000 - 500,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 1|
|CMD1D; CMH2; CMPD2; cTnT; LVNC6; RCM3; TnTC|
|The troponin complex is located on the thin filament of striated muscle and is composed of three component polypeptides: troponin T (TNNT1; TNNT2), troponin I (TNNI1; TNNI2; TNNI3), and troponin C (TNNC) (1). Troponin T type 2 (TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity (2). Troponin T (TnT) anchors the complex to the thin filaments in vertebrate striated muscle, and functions as a regulatory system for muscle contraction in response to changes to intracellular calcium ion concentration (3). All subunits of Tnnt2 have been associated with hypertrophic cardiomyopathy (HCM) (4). |
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Western blot - Cardiac Troponin T antibody [EPR3695]; All lanes : Anti-Cardiac Troponin T antibody [EPR3695] at 1/100000 dilution.Lane 1 : Human heart lysate.Lane 2 : Human skeletal muscle lysate.Lane 3 : Human heart lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/1000 dilution.Predicted band size : 36 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cardiac Troponin T antibody [EPR3695]; TA307717 at 1/100 dilution, staining Cardiac Troponin T in paraffin embedded Human cardiac muscle tissue