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Home Antibody All anti-TNIP3 antibodies

Anti-TNIP3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306824
  • Rabbit Polyclonal ABIN3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC427001) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TNIP3 (NM_001128843)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TNFAIP3 interacting protein 3 (TNIP3), transcript variant 2
Alternative NameABIN-3; LIND
Database LinkNP_001122315
FunctionThe nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of ABIN3 in human spleen tissue lysate with ABIN3 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of ABIN3 in mouse spleen tissue with ABIN3 antibody at 5 ug/ml.

 

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