Home Antibody All anti-TNFSF18 antibodies
Also for TNFSF18 (NM_005092)
|GITRL antibody was raised against purified recombinant human GITR ligand.|
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18)|
|AITRL; GITRL; hGITRL; TL6|
|The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).|
Cytokine-cytokine receptor interaction
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Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 ug/mL.
Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 ug/mL.