Home Antibody All anti-TNFSF13 antibodies
Also for TNFSF13 (NM_003808)
|APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.|
||WB: 1 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 13 (TNFSF13), transcript variant alpha|
|APRIL; CD256; TALL-2; TALL2; TRDL-1; UNQ383/PRO715; ZTNF2|
Entrez Gene 8741 Human
Entrez Gene 69583 Mouse
|Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identified and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kappaB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9).|
|Secreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interaction|
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Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 ug/ml (A), 2 ug/ml (B), and 4 ug/ml (C).
Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 ug/ml.