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Home Antibody All anti-TNFSF12 antibodies

Anti-TNFSF12 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306313
  • Rabbit Polyclonal TWEAK Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418410) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for TNFSF12 (NM_003809)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenTWEAK antibody was raised against recombinant human TWEAK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Purified IgG

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), transcript variant 1
Alternative NameAPO3L; DR3LG; TWEAK
Database LinkNP_003800
FunctionTNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane (1,2). TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis (3), induction of inflammatory cytokines (4), in addition to stimulation of apoptosis (5). The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains (1). Despite its predicted molecular weight of 27kDa, TWEAK may migrate at aberrant positions in SDS-PAGE.
Related Pathway
Cytokine-cytokine receptor interaction

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WB Image
Western blot analysis of (A) 5 ng, (B) 25 ng and (C) 50 ng of recombinant TWEAK with TWEAK antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10 ug/ml.

 

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