Home Antibody All anti-TNFSF12 antibodies
Also for TNFSF12 (NM_003809)
|TWEAK antibody was raised against recombinant human TWEAK.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), transcript variant 1|
|APO3L; DR3LG; TWEAK|
Entrez Gene 8742 Human
Entrez Gene 21944 Mouse
Entrez Gene 360548 Rat
|TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane (1,2). TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis (3), induction of inflammatory cytokines (4), in addition to stimulation of apoptosis (5). The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains (1). Despite its predicted molecular weight of 27kDa, TWEAK may migrate at aberrant positions in SDS-PAGE.|
|Secreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interaction|
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Western blot analysis of (A) 5 ng, (B) 25 ng and (C) 50 ng of recombinant TWEAK with TWEAK antibody at 1 ug/ml.
Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10 ug/ml.