Home Antibody All anti-TNFSF11 antibodies
Also for TNFSF11 (NM_033012)
|Synthetic peptide corresponding to a region within amino acids 1 and 45 of RANKL (Uniprot ID#O14788)|
|Human (Predicted: Mouse, Rat, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (86%), Rat (86%), Bovine (100%)
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2|
|CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TRANCE|
Entrez Gene 8600 Human
Entrez Gene 21943 Mouse
Entrez Gene 117516 Rat
|This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interaction|
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Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308971 diluted at 1:1000.