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Home Antibody All anti-TNFRSF21 antibodies

Anti-TNFRSF21 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306010
  • Rabbit Polyclonal DR6 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402336) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for TNFRSF21 (NM_014452)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenDR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 21 (TNFRSF21)
Alternative NameBM-018; CD358; DR6
Database LinkNP_055267
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappaB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Related Pathway
Apoptosis
Cytokine-cytokine receptor interaction

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WB Image
Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.

 

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