Home Antibody All anti-TNFRSF21 antibodies
Also for TNFRSF21 (NM_014452)
|DR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor .|
||WB: 1:500 - 1:2000
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens tumor necrosis factor receptor superfamily, member 21 (TNFRSF21)|
|BM-018; CD358; DR6|
Entrez Gene 27242 Human
|Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappaB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interaction|
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Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.