Home Antibody All anti-TNFRSF1B antibodies
Also for TNFRSF1B (NM_001066)
|Recombinant protein of human TNFRSF1B|
|Human, Mouse, Rat
||WB: 1:500-1:2000; IHC: 1:50-1:200
|Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)|
|CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80|
Entrez Gene 7133 Human
Entrez Gene 21938 Mouse
Entrez Gene 156767 Rat
|TNF-a is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-a exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-a is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-a have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders.The two receptors for TNF-a, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act throught TNF-R1. In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection. TNF-R2 binds to distinct members of the TRAF family leading to the activation of NF-?B. Soluble forms of both receptors have also been characterized which can bind TNF-a and may play an important role in immune disorders.|
|Secreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionAdipocytokine signaling pathwayAmyotrophic lateral sclerosis (ALS)|
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Western blot analysis of 293 cell and MCF7 cell lysate using TNFRSF1B antibody.