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Anti-TNFRSF1B Antibody EPR1653

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues on the C-terminus in human TNFR2 was used as an immunogen.
Clone Name	EPR1653	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000-10,000; IHC 1:50 - 100;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)
Alternative Name	CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80
Database Link	NP_001057
Function	TNFR2 is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.
Related Pathway	Apoptosis Cytokine-cytokine receptor interaction

Related Lysate from OriGene • Transient overexpression lysate of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • TNFRSF1B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • TNFRSF1B - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Tnfrsf1b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • TNFRSF1B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Tnfrsf1b - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) as transfection-ready DNA • Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) , Myc-DDK-tagged • Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), mGFP tagged Related cDNA Clones • Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)