Home All anti-TNFRSF1B antibodies
Anti-TNFRSF1B Antibody EPR1653
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for TNFRSF1B (NM_001066)
|A synthetic peptide corresponding to residues on the C-terminus in human TNFR2 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000-10,000; IHC 1:50 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B)|
|CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80|
|TNFR2 is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.|
Cytokine-cytokine receptor interaction
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Western blot analysis on (A) Jurkat, (B) MCF-7, (C) SW480, and (D) THP-1 cell lysates using anti-TNFR2 RabMAb.
Immunohistochemical analysis of paraffin-embedded uterus tissue using anti-TNFR2 RabMAb.