Home Antibody All anti-TNFRSF14 antibodies
Also for TNFRSF14 (NM_003820)
|TNFRSF14 antibody was raised against a 15 amino acid peptide from near the amino terminus of human TNFRSF14.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor receptor superfamily, member 14 (TNFRSF14), transcript variant 1|
|ATAR; CD270; HVEA; HVEM; LIGHTR; TR2|
|Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.|
Cytokine-cytokine receptor interaction
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Western blot analysis of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of TNFRSF14 in mouse thymus tissue with TNFRSF14 antibody at 1 ug/ml.