Home Antibody All anti-TNFRSF10C antibodies
Also for TNFRSF10C (NM_003841)
|DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C)|
|CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID|
|Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL (1-3). Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT (2-7) and DcR2/TRAIL-R4/TRUNDD (8-10). DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.|
Cytokine-cytokine receptor interaction
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Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with DcR1 antibody at 1 ug/mL.
Immunofluorescence of DcR1 in rat liver tissue with DcR1 antibody at 10 ug/mL.