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Home Antibody All anti-TNFRSF10C antibodies

Anti-TNFRSF10C Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306046
  • Rabbit Polyclonal DcR1 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TNFRSF10C (NM_003841)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenDcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C)
Alternative NameCD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
Database LinkNP_003832
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL (1-3). Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT (2-7) and DcR2/TRAIL-R4/TRUNDD (8-10). DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Related Pathway
Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with DcR1 antibody at 1 ug/mL.
IF Image
Immunofluorescence of DcR1 in rat liver tissue with DcR1 antibody at 10 ug/mL.

 

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