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Home Antibody All anti-TNFRSF10A antibodies

Anti-TNFRSF10A Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA305966 Rabbit Polyclonal DR4 Antibody 100ug $325 In Stock
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WB(1)
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Also for TNFRSF10A (NM_003844)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenDR4 antibody was raised against a peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:1000
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A)
Alternative NameAPO2; CD261; DR4; TRAILR-1; TRAILR1
Database LinkNP_003835
Entrez Gene 8797 Human
FunctionApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL2,3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)4. DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of DR4 in HeLa (H), K562 (K), and Jurkat (J) whole cell lysate with DR4 antibody at 1:500 dilution.
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