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Anti-TNF Antibody

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SKU Description Amount Price Availability*  
TA323618
  • Anti-TNF Rabbit Polyclonal Antibody
100ul $325 2-3 Weeks
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IHC(2)

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 57-233 amino acids of human tumor necrosis factor
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens tumor necrosis factor (TNF)
Alternative NameDIF; TNF-alpha; TNFA; TNFSF2
Database LinkNP_000585
Entrez Gene 7124 Human
Entrez Gene 21926 Mouse
Entrez Gene 24835 Rat
FunctionThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to; and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation; differentiation; apoptosis; lipid metabolism; and coagulation. This cytokine has been implicated in a variety of diseases; including autoimmune diseases; insulin resistance; and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Related PathwaySecreted ProteinTransmembraneTranscription FactorsDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisTGF-beta signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Predicted cell location: Cytoplasm. Positive control: Human colon and esophagus cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using TNF antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x 200)
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Predicted cell location: Cytoplasm. Positive control: Human colon and esophagus cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using TNF antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x200)
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