Home Antibody All anti-TMEM173 antibodies
Also for TMEM173 (NM_198282)
|MPYS antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transmembrane protein 173 (TMEM173), transcript variant 1|
|ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING|
Entrez Gene 340061 Human
Entrez Gene 72512 Mouse
|MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.|
| RIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/mL.