Home Antibody All anti-TMED10 antibodies
Also for TMED10 (NM_006827)
|TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transmembrane emp24-like trafficking protein 10 (yeast) (TMED10)|
|p23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21|
Entrez Gene 10972 Human
Entrez Gene 68581 Mouse
Entrez Gene 84599 Rat
|TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not theepsilonsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gammasecretase activity.|
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Western blot analysis of TMP21 in mouse brain tissue lysate with TMP21 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 5 ug/ml.