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Home Antibody All anti-TMED10 antibodies

Anti-TMED10 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306375
  • Rabbit Polyclonal TMP21 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402043) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for TMED10 (NM_006827)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenTMP21 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TMP21.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane emp24-like trafficking protein 10 (yeast) (TMED10)
Alternative Namep23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21
Database LinkNP_006818
FunctionTMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
Related Pathway

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WB Image
Western blot analysis of TMP21 in Raji cell lysate with TMP21 antibody at (A) 0.5 and (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of TMP21 in human brain tissue with TMP21 antibody at 2.5 ug/ml.

 

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