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Home Antibody All anti-TMC8 antibodies

Anti-TMC8 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306598 Rabbit Polyclonal EVER2 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenEVER2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human EVER2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane channel-like 8 (TMC8)
Alternative NameEV2; EVER2; EVIN2
Database LinkNP_689681
Entrez Gene 147138 Human
Entrez Gene 217356 Mouse
Entrez Gene 688276 Rat
FunctionEpidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least two isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EVER2 in rat thymus tissue lysate with EVER2 antibody at (A) 1 and (B) 2 µg/ml.


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