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Also for TMC8 (NM_152468)
|EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens transmembrane channel-like 8 (TMC8)|
|EV2; EVER2; EVIN2|
|Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.|
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Western blot analysis of EVER2 in Jurkat cell lysate with EVER2 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of EVER2 in human brain with EVER2 antibody at 5 ug/ml.